Association of 12204590 polymorphism with the development of acute cerebrovascular event

Abstract Purpose To study SNP rs12204590 (T > A) with development of Acute Cerebrovascular Event in the patients cardiovascular pathology and risk factors its who are representatives east Siberian population. Material methods 260 participated a research (age [57.0; 51.0–62.0]) 272 control group [55.0; 51.0–62.0].). Among transferred Event, 157 men 103 women. The included 170 102 Inspection main included: collecting complaints, anamnesis, clinical examination, computer tomography brain, electrocardiography, echo, ultrasonic arteries, daily monitoring arterial blood pressure cardiac rhythm, analysis coagulant system blood. Patients had following factors: hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic disturbances hemostasis. is examined within international HAPIEE project. molecular genetic was conducted by PCR method real time. Statistical processing material carried out use set Statistica for Windows 7.0, Excel SPSS 22 application programs. Results connection genotype TA general confirmed, but no statistically significant associations were obtained when divided into subgroups depending on factors. Conclusion A), compared to genotypes TT AA, reduces developing including hypertension. AA increases males. FUNDunding Acknowledgement Type funding sources: None.